1962 marks the start of a project that became Istituto S. Anna over time. In fact, this is the year when Ezio Pugliese, lawyer from Crotone created an elementary school and a nursery for his daughter Annarella. In the seventies the school became an institution for children with health and social problems, thus moving into the preventive medicine framework. This meant that so many children with borderline problems could receive assistance and education in the new structure.

In the nineties the Institute began its transformation to become what it is today. A project is born with the Department of the Calabria Region leading to the foundation of a clinic that deals with neurorehabilitation. Thanks to the decisive contribution of professor Giuliano Dolce, one of the leading experts on the vegetative state in Europe, the S. Anna discovers a special vocation for patients in coma.

Thus Awakening Unit, the first codified in Italy, an authentic flagship of the Institute, was born. A scientific committee of absolute value is established, and the S. Anna has ongoing exchanges with three international first level centres that work on this typology of patients: Innsbruck, Bordeaux and Tel Aviv, where the staff is sent to train. With the Awakening Unit, all the other units following the patients during their evolution is set up: the Severe Brain Injury Unit, the Intensive Rehabilitation, the Day hospital and the Specialised Long-term unit dedicated to patients in the vegetative state for a long time. Therefore, the Institute is among the first in Italy to apply the Care Continuum operational model that accompanies the patients on an individualised path that is perfectly coherent with their needs, through different levels of care intensity.

The historic building in located at the address via Siris and now there is the modern structure in the locality of Poggio Pudano, Istituto S. Anna is projected onto the fascinating challenge of  scientific research and robotics in the years to come, which has already led to the design, construction and application on the Aramis patients, an acronym for Automatic Recovery Arm Motility Integrated System, an innovative tool for upper limb rehabilitation that is the most advanced treatment of the entire rehabilitation cycle offered to stroke patients. A cutting-edge model for the home care of patients in a vegetative state and minimally conscious state is starting at the Institute: Oberon, a project carried out with new procedures and new technologies providing the hospitalisation at home through an advanced tele-medicine service and the use of a duly coordinated and integrated home care team.